Rilpivirine

ARV U.S. Brand Name
Edurant
ARV Abbreviation(s)
RPV
U.S. FDA Label
Rilpivirine Labeling (Package Insert)
ARV Class
Nonnucleoside reverse transcriptase inhibitors
First U.S. Approval
U.S. Manufacturer
Janssen
Formulations
Strength Formulation Image Description Boosted
25 mg
Film-Coated Tablets
round white tablet
round white tablet with 25 imprint
No
Generic Available?
No
FDCs
Cabotegravir / Rilpivirine IM
Dolutegravir / Rilpivirine
Emtricitabine / Rilpivirine / Tenofovir alafenamide
Emtricitabine / Rilpivirine / Tenofovir DF
Assistance Programs
Janssen Care Path
Displaying 1 - 30 of 30
Interaction Color Code Clinical Bottom Line Clinical Effects Drug 1 effect Drug 2 dose Drug 2 effect Management
Rilpivirine Esomeprazole 123 Red: Avoid combination Do not coadminister: Reduced levels of rilpivirine

Decreased rilpivirine effects

Contraindicated. Use alternative agents.
Darunavir RPV 904 Green: Administer standard doses Administer standard doses

Potential for increased rilpivirine adverse effects

No significant change

 150 mg once daily

Cmax decrease 21%, AUC increase 130%, Cmin increase 178%
Tenofovir disoproxil fumarate RPV 730 Green: Administer standard doses Administer standard doses

Potentially increased risk of TDF adverse effects

Cmax increase 19%, AUC increase 23%, Cmin increase 24%

 150 mg once daily

No significant change

Use recommended dose of rilpivirine 25 mg
Tenofovir alafenamide RPV 704 Green: Administer standard doses Administer standard doses

Cmax increased 1%, AUC increased 1%

 25 mg once daily

Cmax decreased 7%, AUC increased 1%, Cmin increased 13%
Rilpivirine RFB 665 Red: Avoid combination Do not coadminister: Reduced levels of rilpivirine

Decreased rilpivirine effects

Rilpivirine AUC decreased 46%; Cmin decreased 49%; Cmax decreased 35%

 300 mg daily

Use alternative agents
Rilpivirine RIF 664 Red: Avoid combination Do not coadminister: Reduced levels of rilpivirine

Decreased rilpivirine effects

Rilpivirine AUC decreased 80%; Cmin decreased 89%; Cmax decreased 69%

 600 mg daily

No significant change

Use alternative agents
Rilpivirine Omeprazole 663 Red: Avoid combination Do not coadminister: Reduced levels of rilpivirine

Decreased rilpivirine effects

Rilpivirine AUC decreased 40%; Cmin decreased 33%; Cmax decreased 40%

 20 mg daily

No significant change

Contraindicated. Use alternative agents.
Rilpivirine Dasabuvir + Ombitasvir / Paritaprevir / Ritonavir 662 Red: Avoid combination Do not coadminister: Increased levels of rilpivirine

Potential for QT interval prolongation with higher concentrations of RPV.

RPV increased 155%; AUC increased 225%; Cmin increased 262%

 paritaprevir 150 mg with ritonavir 100 mg with ombitasvir 25 mg daily + dasabuvir 250 mg BID

Dasabuvir Cmax increased 18%; AUC increased 17%; Cmin increased 10%. Ombitasvir AUC increased 9%. Paritaprevir Cmin increased 30%, AUC increased 23%; Cmin decreased 5%.

Use alternative agents
Rilpivirine RPT 661 Red: Avoid combination Do not coadminister: Reduced levels of rilpivirine
Rilpivirine St. John's Wort (Hypericum perforatum) 660 Red: Avoid combination Contraindicated
Rilpivirine Oxcarbazepine 659 Red: Avoid combination Contraindicated
Rilpivirine CBZ 658 Red: Avoid combination Contraindicated
Rilpivirine SOF/VEL 657 Green: Administer standard doses Administer standard doses

Rilpivirine Cmin decreased 7%

 400 mg / 100 mg
Rilpivirine Famotidine 656 Green: Administer standard doses Administer standard doses

Rilpivirine Cmax increased 21%

 40 mg x 1 taken 4 hours after rilpivirine
Rilpivirine Famotidine 655 Green: Administer standard doses Administer standard doses

No significant change

 40 mg x 1 taken 12 hours before rilpivirine
Rilpivirine SOF 654 Green: Administer standard doses Administer standard doses 400 mg x 1

Sofosbuvir Cmax increased 21%
Rilpivirine Chlorzoxazone 653 Green: Administer standard doses Administer standard doses

Rilpivirine AUC increased 25%; Cmin increased 18%; Cmax increased 17%

 500 mg x 1

No significant change
Rilpivirine Sildenafil 652 Green: Administer standard doses Administer standard doses

No significant change

 50 mg x 1

No significant change
Rilpivirine Simeprevir 651 Green: Administer standard doses Administer standard doses

Rilpivirine Cmin increased 25%

 150 mg daily x 11 days

No significant change
Rilpivirine Ethinyl estradiol / Norethindrone acetate 650 Green: Administer standard doses Administer standard doses

No significant change

 0.035 mg daily ethinyl estradiol with 1 mg norethindrone daily

Ethinyl estradiol Cmax increased 17%; Norethindrone: no significant change
Rilpivirine DTG 649 Green: Administer standard doses Administer standard doses

Rilpivirine Cmin increased 21%

 50 mg daily

Dolutegravir Cmin increased 22%
Rilpivirine Atorvastatin 648 Green: Administer standard doses Administer standard doses

No significant change

 40 mg daily

Atorvastatin Cmin decreased 15%; Cmax increased 35%
Rilpivirine Ketoconazole 647 Green: Administer standard doses Administer standard doses

Decreased ketoconazole effects

Rilvpivirine AUC increased 49%; Cmin increased 76%; Cmax increased 30%

 400 mg daily

Ketoconazole AUC decreased 24%; Cmin decreased 66%; Cmax decreased 15%

Monitor for failure of antifungal therapy
Rilpivirine Famotidine 646 Yellow: Adjust dosing Adjust dosing to avoid reduced levels of rilpivirine

Decreased rilpivirine effects

Rilpivirine AUC decreased 76%; Cmax decreased 85%

 40 mg x 1 taken 2 hours before rilpivirine

Administer H2-antagonist by at least 12 hours before rilpivirine or at least 4 hours after rilpivirine.
Rilpivirine Aluminum and magnesium hydroxide antacid 645 Yellow: Adjust dosing Adjust dosing to avoid reduced levels of rilpivirine

Potentially decreased rilpivirine effects

Administer antacids either at least 2 hours before or at least 4 hours after rilpivirine.
Rilpivirine Methadone 644 Yellow: Adjust dosing Adjust dosing to avoid reduced levels of methadone

Potentially decreased methadone effects (eg, withdrawal)

No significant change

 60-100 mg daily

R-methadone AUC decreased 16%; Cmin decreased 22%; S-methadone AUC decreased 16%; Cmin decreased 21%;

If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Cabotegravir RPV 328 Green: Administer standard doses Administer standard doses

Cmax increased 5%, AUC increased 12%, Cmin increased 14%

 25 mg once daily

Cmax decreased 4%, AUC decreased 1%, Cmin decreased 8%
Raltegravir RPV 314 Green: Administer standard doses Administer standard doses

Raltegravir Cmin increased 27%

 25 mg daily
Dolutegravir RPV 98 Green: Administer standard doses Administer standard doses

Cmax increased 13%, AUC increased 12%, Cmin increased 22%

 25 mg once daily

Cmax increased 10%, AUC increased 6%, Cmin increased 21%
Rilpivirine
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