Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
150 mg daily
Drug 1 effect
Rilvpivirine AUC increased 49%; Cmin increased 76%; Cmax increased 30%
Drug 2
Drug 2 dose
400 mg daily
Drug 2 effect
Ketoconazole AUC decreased 24%; Cmin decreased 66%; Cmax decreased 15%
Clinical Effects
Decreased ketoconazole effects
Management
Monitor for failure of antifungal therapy
Import ID
647
