Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of rilpivirine
Drug 1
Drug 1 dose
150 mg daily
Drug 1 effect
Rilpivirine AUC decreased 40%; Cmin decreased 33%; Cmax decreased 40%
Drug 2
Drug 2 dose
20 mg daily
Drug 2 effect
No significant change
Clinical Effects
Decreased rilpivirine effects
Management
Contraindicated. Use alternative agents.
Alternative Agents
H2-antagonists if administered at least 12 hours before rilpivirine or at least 4 hours after rilpivirine.
Import ID
663
