Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
25 mg daily
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
60-100 mg daily
Drug 2 effect
R-methadone AUC decreased 16%; Cmin decreased 22%; S-methadone AUC decreased 16%; Cmin decreased 21%;
Clinical Effects
Potentially decreased methadone effects (eg, withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose
Import ID
644
