Aluminum and magnesium hydroxide antacid

Drug Class or Subclass

Gastrointestinal secretion and motility agents

Generic

Aluminum and magnesium hydroxide antacid

Brand Name

Maalox, Mylanta, Riopan, Milk of Magnesia

Import ID

162

Displaying 1 - 10 of 10

	Interaction Color Code	Clinical Bottom Line	Clinical Effects	Drug 1 effect	Drug 2 dose	Drug 2 effect	Management
Rilpivirine (IM) Aluminum and magnesium hydroxide antacid	Green: Administer standard doses	Administer standard doses
Atazanavir Aluminum and magnesium hydroxide antacid 772	Yellow: Adjust dosing	Adjust dosing to avoid reduced atazanavir levels					Separate administration of atazanavir / cobicistat and antacids by a minimum of 2 hours.
Rilpivirine Aluminum and magnesium hydroxide antacid 645	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of rilpivirine	Potentially decreased rilpivirine effects				Administer antacids either at least 2 hours before or at least 4 hours after rilpivirine.
Efavirenz Aluminum and magnesium hydroxide antacid 428	Green: Administer standard doses	Administer standard doses		No significant change	30 mL x 1 dose
Cabotegravir Aluminum and magnesium hydroxide antacid 326	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of cabotegravir		Not studied		Not studied	Administer antacids by at least 2 hours before or 4 hours after oral CAB
Raltegravir Aluminum and magnesium hydroxide antacid 321	Red: Avoid combination	Do not coadminister: Reduced levels of raltegravir		Raltegravir AUC decreased 49% if antacid given simultaneously. AUC decreased 51% if antacid given 2 hours before. AUC decreased 30% if antacid given 2 hours after. AUC decreased 19% if antacid given 4 hours before. AUC decreased 32% if antacid given 4 hours after. AUC decreased 11-13% if antacid given 6 hours before or 6 hours after.	20 mL single dose	Not reported	Contraindicated. Use alternative agents.
Raltegravir Aluminum and magnesium hydroxide antacid 320	Red: Avoid combination	Do not coadminister: Reduced levels of raltegravir		Raltegravir AUC decreased 14% if antacid given 12 horus after.	20 mL single dose	Not reported	Contraindicated. Use alternative agents.
Elvitegravir Aluminum and magnesium hydroxide antacid 143	Yellow: Adjust dosing	Adjust dosing to avoid decreased elvitegravir efficacy	Potential decrease in antiretroviral efficacy	AUC decreased 40-50% when administered simultaneously with antacid; AUC decreased 15-20% when administered 2 hours before or after antacid. No change in AUC if separated by 4-hour interval.	Not reported	Not reported	Administer elvitegravir at least 2 hours before or at least 6 hours after supplements that contain polyvalent cations.
Dolutegravir Aluminum and magnesium hydroxide antacid 122	Red: Avoid combination	Do not coadminister: Reduced levels of dolutegravir	Potential decrease in antiretroviral efficacy	Cmax decreased 72%, AUC decreased 74%, Cmin decreased 74%	Maalox given simultaneously as dolutegravir	Not studied	Administer dolutegravir 2 hours before or 6 hours after antacids.
Dolutegravir Aluminum and magnesium hydroxide antacid 90	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of dolutegravir	Potential decrease in antiretroviral efficacy	Cmax decreased 18%, AUC decreased 26%, Cmin decreased 30%	Maalox given 2 hours after dolutegravir	Not studied	Administer dolutegravir 2 hours before or 6 hours after antacids.

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