Isentress / Isentress HD package insert
Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of raltegravir
Drug 1
Drug 1 dose
400 mg BID
Drug 1 effect
Raltegravir AUC decreased 49% if antacid given simultaneously. AUC decreased 51% if antacid given 2 hours before. AUC decreased 30% if antacid given 2 hours after. AUC decreased 19% if antacid given 4 hours before. AUC decreased 32% if antacid given 4 hours after. AUC decreased 11-13% if antacid given 6 hours before or 6 hours after.
Drug 2 dose
20 mL single dose
Drug 2 effect
Not reported
Management
Contraindicated. Use alternative agents.
Alternative Agents
H2-receptor antagonists
Import ID
321
