Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of dolutegravir
Drug 1
Drug 1 dose
50 mg single dose
Drug 1 effect
Cmax decreased 18%, AUC decreased 26%, Cmin decreased 30%
Drug 2 dose
Maalox given 2 hours after dolutegravir
Drug 2 effect
Not studied
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Administer dolutegravir 2 hours before or 6 hours after antacids.
Import ID
90
