Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid decreased elvitegravir efficacy
Drug 1
Drug 1 dose
Not reported
Drug 1 effect
AUC decreased 40-50% when administered simultaneously with antacid; AUC decreased 15-20% when administered 2 hours before or after antacid. No change in AUC if separated by 4-hour interval.
Drug 2 dose
Not reported
Drug 2 effect
Not reported
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Administer elvitegravir at least 2 hours before or at least 6 hours after supplements that contain polyvalent cations.
Import ID
143
