Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of dolutegravir
Drug 1
Drug 1 dose
50 mg single dose
Drug 1 effect
Cmax decreased 72%, AUC decreased 74%, Cmin decreased 74%
Drug 2 dose
Maalox given simultaneously as dolutegravir
Drug 2 effect
Not studied
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Administer dolutegravir 2 hours before or 6 hours after antacids.
Import ID
122
