Artemether / Lumefantrine

Drug Class or Subclass

Generic

Artemether / Lumefantrine

Brand Name

Coartem

Import ID

75

Displaying 1 - 9 of 9

	Interaction Color Code	Clinical Bottom Line	Clinical Effects	Drug 1 effect	Drug 2 dose	Drug 2 effect	Management
Lenacapavir Artemether/Lumefantrine	Yellow: Adjust dosing	Minimal data to guide interaction: weigh risks and benefits of using this combination	Potential increased risk of lumefantrine adverse effects				If coadministering, monitor for lumefantrine adverse effects (e.g. QT prolongation)
Darunavir Artemether / Lumefantrine 1000	Orange: Minimal data to guide interaction	Minimal data to guide interaction: weigh risks and benefits of using this combination	Clinical significance unknown	No significant change	80 / 480 mg	AUC decrease 16%; AUC increase 175%	If coadministering monitor closely for anti- malarial efficacy and lumefantrine toxicity. Dose adjustment not established.
Nevirapine Artemether / Lumefantrine 612	Red: Avoid combination	Do not coadminister: Reduced levels of arthemether / lumifantrine			artemether / lumefantrine 80 mg / 480 mg x 6 doses	Lumefantrine AUC increased 56%; Cmax increased 24%; half-life: no significant change; clearance: decreased 36%	Use alternative agents
Nevirapine Artemether / Lumefantrine 611	Red: Avoid combination	Do not coadminister: Reduced levels of arthemether / lumifantrine	Potentially increased treatment failure		artemether / lumefantrine 80 / 480 mg	Lumefantrine AUC decreased 21%; Cmax decreased 30%	Use alternative agents
Nevirapine Artemether / Lumefantrine 610	Red: Avoid combination	Do not coadminister: Reduced levels of arthemether / lumifantrine	Potentially increased treatment failure		artemether / lumefantrine 80 / 480 mg	Artemether AUC decreased 72%; Cmax decreased 61%; Lumefantrine AUC decreased 21%; Cmax decreased 30%	Use alternative agents
Etravirine Artemether / Lumefantrine 562	Orange: Minimal data to guide interaction	Minimal data to guide interaction: risks likely to outweigh benefits	Decreased antimalarial effects	No significant change	artemether / lumefantrine 80 / 480 mg	Artemether AUC decreased 38%; Lumefantrine AUC decreased 13%	Use with caution; avoid if possible
Efavirenz Artemether / Lumefantrine 472	Orange: Minimal data to guide interaction	Consider using alternative agents	Potentially compromised antimalarial activity		artemether 20mg / lumefantrine 120 mg 4 tablets / dose for 6 doses total in 3 days	Aremether AUC decreased 79%, Lumefantrine AUC decreased 30%-56%.	If coadministering,dose adjustment not established. Monitor for anti-malarial efficacy.
Efavirenz Artemether / Lumefantrine 471	Orange: Minimal data to guide interaction	Consider using alternative agents	Potentially compromised antimalarial activity	EFV AUC decreased 17%	artemether 20mg / lumefantrine 120 mg 4 tablets / dose for 6 doses total in 3 days	Aremether AUC decreased 51%, Cmax decreased 21% Lumefantrine AUC decreased 21%.	If coadministering,dose adjustment not established. Monitor for anti-malarial efficacy.
Efavirenz Artemether / Lumefantrine 470	Orange: Minimal data to guide interaction	Consider using alternative agents	Potentially compromised antimalarial activity		artemether 20mg / lumefantrine 120 mg 4 tablets / dose for 6 doses total in 3 days	Aremether AUC decreased 51%, Cmax decreased 21% Lumefantrine AUC decreased 21%	If coadministering,dose adjustment not established. Monitor for anti-malarial efficacy.

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