Interaction Color Code
Clinical Bottom Line
Consider using alternative agents
Drug 1
Drug 1 dose
600 mg daily x 26 days
Drug 1 effect
EFV AUC decreased 17%
Drug 2
Drug 2 dose
artemether 20mg / lumefantrine 120 mg 4 tablets / dose for 6 doses total in 3 days
Drug 2 effect
Aremether AUC decreased 51%, Cmax decreased 21% Lumefantrine AUC decreased 21%.
Clinical Effects
Potentially compromised antimalarial activity
Management
If coadministering,dose adjustment not established. Monitor for anti-malarial efficacy.
Import ID
471
