Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of arthemether / lumifantrine
Drug 1
Drug 2
Drug 2 dose
artemether / lumefantrine 80 / 480 mg
Drug 2 effect
Artemether AUC decreased 72%; Cmax decreased 61%; Lumefantrine AUC decreased 21%; Cmax decreased 30%
Clinical Effects
Potentially increased treatment failure
Management
Use alternative agents
Import ID
610
