Calcium carbonate

Drug Class or Subclass

Gastrointestinal secretion and motility agents

Generic

Calcium carbonate

Brand Name

Tums, Oysco, Calcium Antacid

Import ID

163

Displaying 1 - 10 of 10

	Interaction Color Code	Clinical Bottom Line	Clinical Effects	Drug 1 effect	Drug 2 dose	Drug 2 effect	Management
Raltegravir Calcium carbonate 323	Red: Avoid combination	Do not coadminister: Reduced levels of raltegravir		Raltegravir AUC decreased 72%; Cmin decreased 48%	3000 mg single dose given with raltegravir	Not reported	Contraindicated. Use alternative agents.
Raltegravir Calcium carbonate 322	Red: Avoid combination	Do not coadminister: Reduced levels of raltegravir		Raltegravir AUC decreased 10%; Cmin decreased 57%	3000 mg single dose given 12 hours after raltegravir	Not reported	Contraindicated. Use alternative agents.
Raltegravir Calcium carbonate 294	Green: Administer standard doses	Administer standard doses		Raltegravir AUC decreased 55%; Cmin decreased 32%	3000 mg single dose	Not reported
Elvitegravir Calcium carbonate 147	Yellow: Adjust dosing	Adjust dosing to avoid decreased elvitegravir efficacy	Potential decrease in antiretroviral efficacy				Separate elvitegravir / cobicistat from medications containing polyvalent cations by at least 2 hours.
Elvitegravir Calcium carbonate 146	Yellow: Adjust dosing	Adjust dosing to avoid decreased elvitegravir efficacy	Potential decrease in antiretroviral efficacy				Separate elvitegravir / cobicistat from medications containing polyvalent cations by at least 2 hours.
Dolutegravir Calcium carbonate 93	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of dolutegravir	Potential decrease in antiretroviral efficacy if taken without food	Cmax decreased 37%, AUC decreased 39%, Cmin decreased 39% if taken together, fasting conditions. No significant change in dolutegravir AUC if taken 2 hours before calcium carbonate or if taken simultaneously with food.	1200 mg	Not studied	Administer dolutegravir 2 hours before or 6 hours after calcium-containing supplements. Alternatively, administer dolutegravir simulatenously with calcium supplements and with food.
Dolutegravir Calcium carbonate 92	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of dolutegravir	Potential decrease in antiretroviral efficacy if taken without food	Cmax decreased 37%, AUC decreased 39%, Cmin decreased 39% if taken together, fasting conditions. No significant change in dolutegravir AUC if taken 2 hours before calcium carbonate or if taken simultaneously with food.	1200 mg	Not studied	Administer dolutegravir 2 hours before or 6 hours after calcium-containing supplements. Alternatively, administer dolutegravir simulatenously with calcium supplements and with food.
Dolutegravir Calcium carbonate 91	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of dolutegravir	Potential decrease in antiretroviral efficacy if taken without food	Cmax decreased 37%, AUC decreased 39%, Cmin decreased 39% if taken together, fasting conditions. No significant change in dolutegravir AUC if taken 2 hours before calcium carbonate or if taken simultaneously with food.	1200 mg	Not studied	Administer dolutegravir 2 hours before or 6 hours after calcium-containing supplements. Alternatively, administer dolutegravir simulatenously with calcium supplements and with food.
Bictegravir Calcium carbonate 64	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of bictegravir	Potential decrease in antiretroviral efficacy	If administered simultaneously in the fasted state Cmax decreased 42%, AUC decreased 33%. If administered simultaneously in the fed state Cmax decreased 10%, AUC increased 3%	1200 mg single dose	Not reported	Bictegravir should be administered simultaenously with calcium carbonate supplements, with food.
Bictegravir Calcium carbonate 63	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of bictegravir	Potential decrease in antiretroviral efficacy	If administered simultaneously in the fasted state Cmax decreased 42%, AUC decreased 33%. If administered simultaneously in the fed state Cmax decreased 10%, AUC increased 3%	1200 mg single dose	Not reported	Bictegravir should be administered simultaenously with calcium carbonate supplements, with food.

Subscribe to Calcium carbonate