Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of dolutegravir
Drug 1
Drug 1 dose
50 mg single dose
Drug 1 effect
Cmax decreased 37%, AUC decreased 39%, Cmin decreased 39% if taken together, fasting conditions. No significant change in dolutegravir AUC if taken 2 hours before calcium carbonate or if taken simultaneously with food.
Drug 2
Drug 2 dose
1200 mg
Drug 2 effect
Not studied
Clinical Effects
Potential decrease in antiretroviral efficacy if taken without food
Management
Administer dolutegravir 2 hours before or 6 hours after calcium-containing supplements. Alternatively, administer dolutegravir simulatenously with calcium supplements and with food.
Import ID
91
