Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of bictegravir
Drug 1
Drug 1 dose
50 mg single dose
Drug 1 effect
If administered simultaneously in the fasted state Cmax decreased 42%, AUC decreased 33%. If administered simultaneously in the fed state Cmax decreased 10%, AUC increased 3%
Drug 2
Drug 2 dose
1200 mg single dose
Drug 2 effect
Not reported
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Bictegravir should be administered simultaenously with calcium carbonate supplements, with food.
Import ID
64
