Isentress / Isentress HD package insert
Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of raltegravir
Drug 1
Drug 1 dose
1200 mg (HD) single dose
Drug 1 effect
Raltegravir AUC decreased 10%; Cmin decreased 57%
Drug 2
Drug 2 dose
3000 mg single dose given 12 hours after raltegravir
Drug 2 effect
Not reported
Management
Contraindicated. Use alternative agents.
Alternative Agents
H2-receptor antagonists
Import ID
322
