Generic
Colchicine
Brand Name
Colcrys, Mitigare
Import ID
67
Colchicine
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Colchicine | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of GI adverse effects |
If using for gout flare may coadminister a single dose of 1.2 mg. May not repeat dose for at least 3 days. If using for Familiar Mediterranean Fever do not exceed colchicine dose of 1.2 mg daily. |
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| Ritonavir Colchicine 1039 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of colchicine | Increased colchicine effects |
0.6 mg x 1 | Colchicine AUC increased 296%; Cmax increased 184% |
For treatment of gout, reduce colchicine dosage to 0.6 mg x 1 then 0.3 mg one hour later. Dose should not be repeated earlier than 3 days after. For gout prophylaxis, reduce colchicine dose to 0.3 mg daily if on 0.6 mg BID prior to PI therapy or reduce colchicine dose to 0.3 mg every other day if on 0.6 mg daily prior to PI therapy. For treatment of familial Mediterranean fever do not exceed colchicine 0.6 mg once daily or 0.3 mg BID. Do not coadminister in patients with hepatic or renal impairment. |
|
| Darunavir Colchicine 881 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of colchicine | Increased risk of colchicine adverse effects |
For treatment of gout, reduce colchicine dosage to 0.6 mg x 1 then 0.3 mg one hour later. Dose should not be repeated earlier than 3 days after. For gout prophylaxis, reduce colchicine dose to 0.3 mg daily if on 0.6 mg BID prior to PI therapy or reduce colchicine dose to 0.3 mg every other day if on 0.6 mg daily prior to PI therapy. For treatment of familial Mediterranean fever do not exceed colchicine 0.6 mg once daily or 0.3 mg BID. Do not coadminister in patients with hepatic or renal impairment. |
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| Atazanavir Colchicine 757 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of colchicine | Potential for increased colchicine effects |
For treatment of gout, reduce colchicine dosage to 0.6 mg x 1 then 0.3 mg one hour later. Dose should not be repeated earlier than 3 days after. For gout prophylaxis, reduce colchicine dose to 0.3 mg daily if on 0.6 mg BID prior to PI therapy or reduce colchicine dose to 0.3 mg every other day if on 0.6 mg daily prior to PI therapy. For treatment of familial Mediterranean fever do not exceed colchicine 0.6 mg once daily or 0.3 mg BID. Do not coadminister in patients with hepatic or renal impairment. |
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| Elvitegravir Colchicine 160 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of colchicine | Potential for increased risk of colchicine adverse effects |
If coadministering for treatment of gout flares use 0.6 mg single dose followed by 0.3 mg single dose 1h later and do not repeat for at least 3 days. If coadministering for prophylaxis of gout flares adjust based on original regimen (e.g. reduce 0.6 mg BID to 0.3 mg once daily, reduce 0.6 mg once daily to 0.3 mg every other day). If coadministering for FMF, maximum daily dose is 0.6 mg. Do not coadminister in hepatic or renal impairment. |
