Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of colchicine
Drug 1
Drug 1 dose
100 mg BID x 5 days
Drug 2
Drug 2 dose
0.6 mg x 1
Drug 2 effect
Colchicine AUC increased 296%; Cmax increased 184%
Clinical Effects
Increased colchicine effects
Management
For treatment of gout, reduce colchicine dosage to 0.6 mg x 1 then 0.3 mg one hour later. Dose should not be repeated earlier than 3 days after. For gout prophylaxis, reduce colchicine dose to 0.3 mg daily if on 0.6 mg BID prior to PI therapy or reduce colchicine dose to 0.3 mg every other day if on 0.6 mg daily prior to PI therapy. For treatment of familial Mediterranean fever do not exceed colchicine 0.6 mg once daily or 0.3 mg BID. Do not coadminister in patients with hepatic or renal impairment.
Import ID
1039
