Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of colchicine
Drug 1
Drug 2
Clinical Effects
Potential for increased risk of colchicine adverse effects
Management
If coadministering for treatment of gout flares use 0.6 mg single dose followed by 0.3 mg single dose 1h later and do not repeat for at least 3 days. If coadministering for prophylaxis of gout flares adjust based on original regimen (e.g. reduce 0.6 mg BID to 0.3 mg once daily, reduce 0.6 mg once daily to 0.3 mg every other day). If coadministering for FMF, maximum daily dose is 0.6 mg. Do not coadminister in hepatic or renal impairment.
Import ID
160
