DHHS Adult ARV Guidelines
Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 2
Mechanism
Inhibition of CYP3A4 by lenacapavir
Clinical Effects
Potential increased risk of GI adverse effects
Management
If using for gout flare may coadminister a single dose of 1.2 mg. May not repeat dose for at least 3 days. If using for Familiar Mediterranean Fever do not exceed colchicine dose of 1.2 mg daily.
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