Label
No interactions expected
Color
Green
Green: Administer standard doses
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Maraviroc RPT 58 | Green: Administer standard doses | Do not coadminister: Potential for reduced levels of maraviroc | Potential decrease in antiretroviral efficacy |
Use alternative agents |
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| Maraviroc RAL 57 | Green: Administer standard doses | Administer standard doses | Maraviroc AUC decreased 14%; Cmax decreased 21% |
400 mg BID | Raltegravir AUC decreased 37%; Cmin decreased 27% |
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| Maraviroc NVP 56 | Green: Administer standard doses | Administer standard doses | Maraviroc AUC no change; Cmax increased 54% |
200 mg BID | Not reported |
||
| Maraviroc RFB 55 | Green: Administer standard doses | Administer standard doses | Maraviroc AUC no change; Cmin decreased 30% |
300 mg daily | Not reported |
||
| Fostemsavir RAL + TDF 16 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 23%, AUC increased 7%, Cmin increased 17% |
RAL 400 mg BID, TDF 300 mg once daily | Not reported |
||
| Fostemsavir Famotidine 15 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 1%, AUC increased 4%, Cmin decreased 10% |
40mg single dose | Not reported |
||
| Fostemsavir Methadone 14 | Green: Administer standard doses | Administer standard doses | Not studied |
40-120mg once daily, individual dosing | Methadone R(-): Cmax increased 15%, AUC increased 13%. Methadone S(+): Cmax increased 15%, AUC increased 15%, Cmin increased 10%. Methadone (total): Cmax increased 25%, AUC increased 14%, Cmin increased 10% |
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| Fostemsavir MVC 13 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 13%, AUC increased 10%, Cmin decreased 10% |
300 mg BID | Maraviroc AUC increased 25%, Cmin increased 37% |
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| Fostemsavir Buprenorphine / naloxone 12 | Green: Administer standard doses | Administer standard doses | Not studied |
8mg / 2mg to 24mg / 6mg once daily, individual dosing | Buprenorphine Cmax increased 24%, AUC increased 30%, Cmin increased 39%. Norbuprenorphine Cmax increased 24%, AUC increased 39%, Cmin increased 39% |
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| Fostemsavir DRV/c 11 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 79%, AUC increased 97%, Cmin increased 124% |
800 / 150 mg once daily | Not studied |
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| Fostemsavir Cobi 10 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 71%, AUC increased 93%, Cmin increased 136% |
150 mg once daily | Not studied |
||
| Fostemsavir RTV 9 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 53%, AUC increased 45%, Cmin increased 44% |
100 mg once daily | Not reported |
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| Fostemsavir DRV/r + ETR 8 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 53%, AUC increased 34%, Cmin increased 33% |
DRV 600mg twice daily, / r 100mg twice daily, ETR 200mg twice daily | DRV and ritonavir no significant changes. Etravirine Cmax increased 18%, AUC increased 28%, Cmin increased 28%. |
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| Fostemsavir DRV/r 7 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 52%, AUC increased 63%, Cmin increased 88% |
DRV 600mg twice daily, / r 100mg twice daily | DRV no significant change. Ritonavir AUC increased 15%, Cmin increased 19% |
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| Fostemsavir ATV/r 6 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax increased 68%, AUC increased 54%, Cmin increased 57% |
ATV 300mg, / r 100mg once daily | ATV: Cmax increased 3%, AUC increased 9%, Cmin increased 19%; / r: Cmax increased 2%, AUC increased 7%, Cmin increased 22% |
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| Fostemsavir ETR 5 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax decreased 48%, AUC decreased 50%, Cmin decreased 48% |
200 mg BID | Etravirine Cmax increased 11%, AUC increased 11%, Cmin increased 14% |
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| Fostemsavir TDF 4 | Green: Administer standard doses | Administer standard doses | Temsavir Cmax decreased 1%, Cmin increased 13% |
300 mg once daily | Cmax increased 18%, AUC increased 19%, Cmin increased 28% |
