Fostemsavir Methadone 14 | HIV Care Tools Drug Interactions Database

Rukobia package insert

Interaction Color Code

Green: Administer standard doses

Clinical Bottom Line

Administer standard doses

Drug 1

Fostemsavir

Drug 1 dose

600 mg BID

Drug 1 effect

Not studied

Drug 2

Methadone

Drug 2 dose

40-120mg once daily, individual dosing

Drug 2 effect

Methadone R(-): Cmax increased 15%, AUC increased 13%. Methadone S(+): Cmax increased 15%, AUC increased 15%, Cmin increased 10%. Methadone (total): Cmax increased 25%, AUC increased 14%, Cmin increased 10%

Import ID