Generic
Tadalafil
Brand Name
Cialis, Adcirca
Import ID
142
Tadalafil
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Tadalafil | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased risk of tadalafil adverse effects (e.g. flushing, headache, hypotension) |
Pulmonary arterial hypertension: coadministration of lenacapavir with tadalafil is not recommended. Erectile dysfunction: When used on an "as needed" basis, tadalafil dose should not exceed 10 mg every 72 hours. If used once daily (chronic administration), tadalafil dose should not exceed 2.5 mg daily. |
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| Ritonavir Tadalafil 1046 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of tadalafil | Increased tadalafil effects (eg, hypotension, priapism) |
20 mg x 1 | Tadalafil AUC increased 32%, Cmax decreased 30% |
For erectile dysfunction initiate tadalafil 5 mg dose and do not exceed 10 mg every 72 hours. Monitor adverse effects. For patients taking a protease inhibitor (stable > 7 days) requiring tadalafil for pulmonary arterial hypertension initiate 20 mg once daily and increase to 40 mg once daily based on tolerability. Patients currently on tadalafil who require a PI should stop tadalafil ³24 hours before PI initiation, take the PI for 7 days, then resume tadalafil at 20 mg. Maximum recommended daily dose for treatment of BPH is 2.5 mg daily. |
|
| Ritonavir Tadalafil 1045 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of tadalafil | Increased tadalafil effects (eg, hypotension, priapism) |
20 mg x 1 | Tadalafil AUC increased 124% |
For erectile dysfunction initiate tadalafil 5 mg dose and do not exceed 10 mg every 72 hours. Monitor adverse effects. For patients taking a protease inhibitor (stable > 7 days) requiring tadalafil for pulmonary arterial hypertension initiate 20 mg once daily and increase to 40 mg once daily based on tolerability. Patients currently on tadalafil who require a PI should stop tadalafil ³24 hours before PI initiation, take the PI for 7 days, then resume tadalafil at 20 mg. Maximum recommended daily dose for treatment of BPH is 2.5 mg daily. |
|
| Darunavir Tadalafil 890 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of tadalafil | Increased risk of tadalafil adverse effects (e.g. hypotension, priapism) |
Not studied |
Not studied (may increase tadalafil levels) |
For erectile dysfunction, initiate tadalafil 5 mg dose and do not exceed 10 mg every 72 hours. Monitor adverse effects. For patients taking a protease inhibitor (stable > 7 days) requiring tadalafil for pulmonary arterial hypertension, initiate 20 mg once daily and increase to 40 mg once daily based on tolerability. Patients currently on tadalafil who require a PI should stop tadalafil ³24 hours before PI initiation, take the PI for 7 days, then resume tadalafil at 20 mg. Maximum recommended daily dose for treatment of BPH is 2.5 mg daily. |
|
| Atazanavir Tadalafil 771 | Yellow: Adjust dosing | Adjust dosing to avoid increased tadalafil levels | Potentially increased tadalafill effects (eg, hypotension, priapism) |
For erectile dysfunction initiate tadalafil 5 mg dose and do not exceed 10 mg every 72 hours. Monitor adverse effects. For patients taking a protease inhibitor (stable > 7 days) requiring tadalafil for pulmonary arterial hypertension initiate 20 mg once daily and increase to 40 mg once daily based on tolerability. Patients currently on tadalafil who require a PI should stop tadalafil ³24 hours before PI initiation, take the PI for 7 days, then resume tadalafil at 20 mg. Maximum recommended daily dose for treatment of BPH is 2.5 mg daily. |
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| Elvitegravir Tadalafil 173 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of tadalafil | Potential for increased tadalafil effects (e.g. hypotension, priapism) |
For erectile dysfunction, initiate tadalafil 5 mg dose and do not exceed 10 mg every 72 hours. Monitor adverse effects. For patients taking a protease inhibitor (stable > 7 days) requiring tadalafil for pulmonary arterial hypertension initiate 20 mg once daily and increase to 40 mg once daily based on tolerability. Patients currently on tadalafil who require a PI should stop tadalafil ³24 hours before PI initiation, take the PI for 7 days, then resume tadalafil at 20 mg. Maximum recommended daily dose for treatment of BPH is 2.5 mg daily. |
