Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of tadalafil
Drug 1
Drug 1 effect
Not studied
Drug 2
Drug 2 effect
Not studied (may increase tadalafil levels)
Clinical Effects
Increased risk of tadalafil adverse effects (e.g. hypotension, priapism)
Management
For erectile dysfunction, initiate tadalafil 5 mg dose and do not exceed 10 mg every 72 hours. Monitor adverse effects. For patients taking a protease inhibitor (stable > 7 days) requiring tadalafil for pulmonary arterial hypertension, initiate 20 mg once daily and increase to 40 mg once daily based on tolerability. Patients currently on tadalafil who require a PI should stop tadalafil ³24 hours before PI initiation, take the PI for 7 days, then resume tadalafil at 20 mg. Maximum recommended daily dose for treatment of BPH is 2.5 mg daily.
Import ID
890
