Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of tadalafil
Drug 1
Drug 1 dose
500 mg or 600 mg BID
Drug 2
Drug 2 dose
20 mg x 1
Drug 2 effect
Tadalafil AUC increased 32%, Cmax decreased 30%
Clinical Effects
Increased tadalafil effects (eg, hypotension, priapism)
Management
For erectile dysfunction initiate tadalafil 5 mg dose and do not exceed 10 mg every 72 hours. Monitor adverse effects. For patients taking a protease inhibitor (stable > 7 days) requiring tadalafil for pulmonary arterial hypertension initiate 20 mg once daily and increase to 40 mg once daily based on tolerability. Patients currently on tadalafil who require a PI should stop tadalafil ³24 hours before PI initiation, take the PI for 7 days, then resume tadalafil at 20 mg. Maximum recommended daily dose for treatment of BPH is 2.5 mg daily.
Import ID
1046
