Generic
Sildenafil
Brand Name
Viagra, Revatio
Import ID
141
Sildenafil
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Rilpivirine (IM) Sildenafil | Green: Administer standard doses | Administer standard doses | |||||
| Lenacapavir Sildenafil | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Increased risk of sildenafil adverse effects (e.g. flushing, headache, hypotension). |
Use of PDE-5 inhibitors for pulmonary arterial hypertension (PAH): Concomitant administration of SUNLENCA with tadalafil for the treatment of PAH is not recommended. Use of PDE-5 inhibitors for erectile dysfunction (ED): Refer to the prescribing information of sildenafil for dose recommendations. Use of PDE-5 inhibitors for pulmonary arterial hypertension (PAH): Do not coadminaster sildenafil with Lenacapavir. Use of PDE-5 inhibitors for erectile dysfunction (ED): Adjust dosing to avoid increased levels sildenafil |
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| Ritonavir Sildenafil 1044 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of sildenafil. (Do not coadminister for pulmonary hypertension) | Increased sildenafil effects (eg, hypotension, priapism) |
100 mg x 1 dose | Sildenafil AUC increased 1000%; Cmax increased 290%; Tmax: delayed 3 hours |
For erectile dysfunction, initiate sildenafil 25 mg every 48 hours and monitor for adverse effects. Manufacturer recommends not to exceed dose of 25 mg every 48 hours. Do not coadminister if using sildenafil for pulmonary arterial hypertension. |
|
| Darunavir Sildenafil 889 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of sildenafil. (Do not coadminister for pulmonary hypertension) | Increased risk of sildenafil adverse effects (e.g. hypotension, priapism) |
Not reported |
25 mg x 1 | Cmax decrease 38% (compared to sildenafil 100 mg x 1 without darunavir / ritonavir) |
For erectile dysfunction, do not exceed sildenafil 25 mg every 48 hours and monitor for adverse effects. Contraindicated if using sildenafil for pulmonary arterial hypertension. |
| Atazanavir Sildenafil 770 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of sildenafil. (Do not coadminister for pulmonary hypertension) | Potentially increased sildenafil effects (eg, hypotension, priapism) |
For erectile dysfunction, initiate sildenafil (Viagra) 25 mg every 48 hours and monitor for adverse effects. Do not coadminister if using sildenafil for pulmonary arterial hypertension. |
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| Rilpivirine Sildenafil 652 | Green: Administer standard doses | Administer standard doses | No significant change |
50 mg x 1 | No significant change |
||
| Etravirine Sildenafil 523 | Green: Administer standard doses | Administer standard doses | Decreased sildenafil effects |
50 mg x 1 | Sildenafil AUC decreased 57%; Cmax decreased 45% |
Monitor for sildenafil efficacy and titrate to effect |
|
| Elvitegravir Sildenafil 172 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of sildenafil. | Potential for increased sildenafil effects (eg, hypotension, priapism, visual disturbances) |
For erectile dysfunction, initiate sildenafil 25 mg every 48 hours and monitor for adverse effects. Manufacturer recommends not to exceed dose of 25 mg every 48 hours. Do not coadminister if using sildenafil for pulmonary arterial hypertension. |
