Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of sildenafil. (Do not coadminister for pulmonary hypertension)
Drug 1
Drug 1 dose
400 mg with 100 mg ritonavir BID
Drug 1 effect
Not reported
Drug 2
Drug 2 dose
25 mg x 1
Drug 2 effect
Cmax decrease 38% (compared to sildenafil 100 mg x 1 without darunavir / ritonavir)
Clinical Effects
Increased risk of sildenafil adverse effects (e.g. hypotension, priapism)
Management
For erectile dysfunction, do not exceed sildenafil 25 mg every 48 hours and monitor for adverse effects. Contraindicated if using sildenafil for pulmonary arterial hypertension.
Import ID
889
