Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of sildenafil. (Do not coadminister for pulmonary hypertension)
Drug 1
Drug 1 dose
300 mg, 400 mg and 500 mg BID on days 2, 3 and 4-8
Drug 2
Drug 2 dose
100 mg x 1 dose
Drug 2 effect
Sildenafil AUC increased 1000%; Cmax increased 290%; Tmax: delayed 3 hours
Clinical Effects
Increased sildenafil effects (eg, hypotension, priapism)
Management
For erectile dysfunction, initiate sildenafil 25 mg every 48 hours and monitor for adverse effects. Manufacturer recommends not to exceed dose of 25 mg every 48 hours. Do not coadminister if using sildenafil for pulmonary arterial hypertension.
Import ID
1044
