Generic
Digoxin
Brand Name
Lanoxin
Import ID
122
Digoxin
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Rilpivirine (IM) Digoxin | Green: Administer standard doses | Administer standard doses | |||||
| Lenacapavir Digoxin | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of digoxin adverse effects |
Use with caution and monitor digoxin therapeutic concentration |
|||
| Ritonavir Digoxin 1040 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of digoxin | Increased digoxin effects |
0.4 mg x 1 dose | Digoxin AUC (0-8 hr): increased 29%; AUC (0-72 hr): increased 22%; clearance: decreased 30%; half-life: increased 43% |
Digoxin dose may need to be decreased. Monitor digoxin level and adjust digoxin dose based on clinical signs and drug levels. |
|
| Darunavir Digoxin 882 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of digoxin | Increased risk of digoxin adverse effects |
Not reported |
0.4 mg x 1 | Cmax increase 15%, AUC increase 36% |
Initiate lowest dose digoxin and titrate to desired clinical effect |
| Atazanavir Digoxin 852 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of digoxin toxicity |
If coadministering digoxin dose may need to be decreased. Monitor digoxin level and adjust digoxin dose based on clinical signs and drug levels. |
|||
| Elvitegravir Digoxin 126 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased digoxin adverse effects |
Not reported |
0.5 mg single dose | Cmax increased 41%, AUC increased 8% |
If coadministering, use with caution. Monitor levels and digoxin adverse effects |
