Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of digoxin
Drug 1
Drug 1 dose
200 mg BID x 15 days
Drug 2
Drug 2 dose
0.4 mg x 1 dose
Drug 2 effect
Digoxin AUC (0-8 hr): increased 29%; AUC (0-72 hr): increased 22%; clearance: decreased 30%; half-life: increased 43%
Clinical Effects
Increased digoxin effects
Management
Digoxin dose may need to be decreased. Monitor digoxin level and adjust digoxin dose based on clinical signs and drug levels.
Import ID
1040
