Generic
Apixaban
Brand Name
Eliquis
Import ID
114
Apixaban
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Apixaban | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of bleeding |
Use with caution. Monitor for apixaban adverse effects (e.g. bleeding) |
|||
| Ritonavir Apixaban 1094 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of bleeding |
Not studied |
Not studied (may increase levels) of apixaban. |
Avoid combination; use alternative anticoagulant |
|
| Darunavir Apixaban 983 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased bleeding risk |
Do not coadminister in patients who require apixaban 2.5 mg twice daily. In patients requiring apixaban 5 mg or 10 mg twice daily, reduce apixaban dose by 50% |
|||
| Darunavir Apixaban 966 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased bleeding risk |
Avoid combination; use alternative anticoagulant |
|||
| Atazanavir Apixaban 865 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefitsÊof using this combination | Increased apixaban levels, Potential for increased risk of bleeding |
Consider using alternative agents |
|||
| Atazanavir Apixaban 843 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of bleeding |
Avoid combination, use alternative anticoagulant |
|||
| Elvitegravir Apixaban 224 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for increased risk of bleeding |
Consider avoiding combination and using alternative anticoagulant. If coadministering, reduce apixaban dose by 50% in patients who require 5-10 mg twice daily. Do not coadminister in persons who require apixaban 2.5mg twice daily. |
