Darunavir Apixaban 983

Prezista label

Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 2
Clinical Effects

Potential for increased bleeding risk

Management

Do not coadminister in patients who require apixaban 2.5 mg twice daily. In patients requiring apixaban 5 mg or 10 mg twice daily, reduce apixaban dose by 50%

Alternative Agents
Dabigatran
Import ID
983