Daclatasvir

Drug Class or Subclass

Anti-hepatitis C agents

Generic

Daclatasvir

Brand Name

Daklinza

Import ID

96

Displaying 1 - 11 of 11

	Interaction Color Code	Clinical Bottom Line	Clinical Effects	Drug 1 effect	Drug 2 dose	Drug 2 effect	Management
Darunavir Daclatasvir 902	Green: Administer standard doses	Administer standard doses		No significant change	30 mg once daily	No significant change	No dose adjustment necessary
Atazanavir Daclatasvir 759	Yellow: Adjust dosing	Adjust dosing to avoid increased levels of daclatasvir		No significant change	20 mg daily	AUC(tau) increased 110%	Decrease daclatasvir dose to 30 mg daily when used with atazanavir / ritonavir. No dose adjustment necessary if used with unboosted atazanavir.
Atazanavir Daclatasvir 758	Yellow: Adjust dosing	Adjust dosing to avoid increased levels of daclatasvir					Decrease daclatasvir dose to 30 mg daily
Tenofovir disoproxil fumarate Daclatasvir 743	Green: Administer standard doses	Administer standard doses		No significant change	60 mg once daily	No significant change
Nevirapine Daclatasvir 601	Green: Administer standard doses	Administer standard doses		Cmin decreased 16%		Rifabutin AUC increased 17%, metabolite AUC increased 24%
Nevirapine Daclatasvir 576	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of daclatasvir	Potential loss of anti-HCV efficacy	Nevirapine Cmin decreased 16%		Not studied (may decrease daclatasvir levels)	Increase daclatasvir dose to 90 mg daily.
Nevirapine Daclatasvir 575	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of daclatasvir	Potential loss of anti-HCV efficacy		120 mg daily	AUC increased 37% and Cmin decreased 17%.	Increase daclatasvir dose to 90 mg daily.
Etravirine Daclatasvir 515	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of daclatasvir	Potential loss of anti-HCV efficacy	Not studied	120 mg daily	AUC increased 37% and Cmin decreased 17%.	Increase daclatasvir dose to 90 mg daily.
Efavirenz Daclatasvir 361	Yellow: Adjust dosing	Adjust dosing to avoid reduced levels of daclatasvir	Potential loss of anti-HCV efficacy		120 mg daily	Daclatasvir Cmax increased 67%; AUC increased 37%.	Increase daclatasvir dose to 90 mg daily.
Elvitegravir Daclatasvir 161	Yellow: Adjust dosing	Adjust dosing to avoid increased levels of daclatasvir					Decrease daclatasvir dose to 30 mg daily
Dolutegravir Daclatasvir 104	Green: Administer standard doses	Administer standard doses		Cmax increased 29%, AUC increased 33%, Cmin increased 45%	60 mg once daily	No significant change

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