Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of daclatasvir
Drug 1
Drug 1 dose
600 mg daily
Drug 2
Drug 2 dose
120 mg daily
Drug 2 effect
Daclatasvir Cmax increased 67%; AUC increased 37%.
Clinical Effects
Potential loss of anti-HCV efficacy
Management
Increase daclatasvir dose to 90 mg daily.
Import ID
361
