Generic
Fluticasone
Brand Name
Advair, Flovent
Import ID
69
Fluticasone
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Fluticasone | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of corticosteroid adverse effects (e.g. Cushing's syndrome and adrenal supression). |
If coadministering, initiate lowest starting dose and titrate to clinical effect. Monitor for adverse effects such as adrenal insufficiency and Cushing's syndrome. |
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| Ritonavir Fluticasone 1071 | Red: Avoid combination | Do not coadminister: Increased levels of fluticasone | Increased fluticasone effects (eg, Cushing's syndrome, adrenal suppression) |
200 mcg once daily x 7 d | Fluticasone Cmax increased 2572%; AUC increased 36697% |
Avoid combination and use alternative agents |
|
| Ritonavir Fluticasone 1070 | Red: Avoid combination | Do not coadminister: Increased levels of fluticasone | Decreased plasma cortisol concentrations (eg, Cushing's syndrome, adrenal suppression) |
Fluticasone AUC increased 350-fold; Cmax increased 25-fold |
Avoid combination and use alternative agents |
||
| Darunavir Fluticasone 968 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potential for decreased plasma cortisol concentrations (e.g. Cushing's syndrome, adrenal suppression) |
Avoid combination or use alternative agents |
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| Atazanavir Fluticasone 862 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Decreased plasma cortisol concentrations (eg, Cushing's syndrome, adrenal suppression) |
Use with caution with atazanavir, use with atazanavir / ritonavir is not recommended unless the potential benefit outweighs the risk |
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| Elvitegravir Fluticasone 190 | Red: Avoid combination | Do not coadminister: Potential for increased levels of fluticasone | Potential for increased risk of adrenal insufficiency and Cushing's syndrome |
Use alternative agents |
