Interaction Color Code
Clinical Bottom Line
Do not coadminister: Increased levels of fluticasone
Drug 1
Drug 2
Drug 2 effect
Fluticasone AUC increased 350-fold; Cmax increased 25-fold
Clinical Effects
Decreased plasma cortisol concentrations (eg, Cushing's syndrome, adrenal suppression)
Management
Avoid combination and use alternative agents
Import ID
1070
