Generic
Trazodone
Brand Name
Desyrel
Import ID
53
Trazodone
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Trazodone | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of trazodone adverse effects (e.g. sedation, CNS effects) |
If coadministering start with lowest dose and titrate to clinical effect. Monitor for trazodone-related adverse events. |
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| Ritonavir Trazodone 1048 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of trazodone | Increased trazodone effects (eg, nausea, hypotension, syncope) |
Not studied |
50 mg x 1 dose | Trazodone AUC increased 240%; Cmax increased 34%; half-life: increased 220% |
Decrease trazodone dose or start low and titrate to effect |
| Ritonavir Trazodone 1047 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of trazodone | Increased trazodone effects (eg, nausea, dizziness, hypotension, syncope) |
Trazodone AUC increased 2.4-fold; Cmax increased 34% |
Decrease trazodone dose or start low and titrate to effect |
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| Darunavir Trazodone 1013 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of trazodone adverse effects (e.g. nausea, dizziness, hypotension, syncope) |
If coadministering, initiate trazodone at low dose. Monitor for CNS and cardiovascular effects. |
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| Nevirapine Trazodone 590 | Green: Administer standard doses | Administer standard doses | Decreased trazadone effects |
Monitor for signs and symptoms of depression and titrate trazadone to effect |
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| Etravirine Trazodone 570 | Orange: Minimal data to guide interaction | minimal data to guide interaction: weigh risks and benefits of using this combination | Potiential decreaed Trazodone effects |
If coadministring, monitor for theraptutic effectiveness of Trazodone |
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| Elvitegravir Trazodone 176 | Yellow: Adjust dosing | Adjust dosing to avoid increased levels of trazodone | Potential for increased trazodone adverse effects |
If coadministering initiate trazodone at lowest dose. Monitor response and titrate according to efficacy, adverse effects. |
