Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of trazodone
Drug 1
Drug 1 dose
200 mg BID for 2 days
Drug 1 effect
Not studied
Drug 2
Drug 2 dose
50 mg x 1 dose
Drug 2 effect
Trazodone AUC increased 240%; Cmax increased 34%; half-life: increased 220%
Clinical Effects
Increased trazodone effects (eg, nausea, hypotension, syncope)
Management
Decrease trazodone dose or start low and titrate to effect
Import ID
1048
