DHHS Adult ARV Guidelines
Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 2
Mechanism
Inhibition of CYP3A4 by lenacapavir
Clinical Effects
Potential increased risk of trazodone adverse effects (e.g. sedation, CNS effects)
Management
If coadministering start with lowest dose and titrate to clinical effect. Monitor for trazodone-related adverse events.
Info Source
