Generic
Sertraline
Brand Name
Zoloft
Import ID
52
Sertraline
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Darunavir Sertraline 898 | Yellow: Adjust dosing | Adjust dosing to avoid reduced levels of sertraline | Potential decreased sertraline effects |
No significant change |
50 mg once daily | Cmax decrease 44%, AUC decrease 49%, Cmin decrease 49% |
Titrate sertraline to effect; monitor to ensure continued response if darunavir / ritonavir initiated |
| Tenofovir alafenamide Sertraline 705 | Green: Administer standard doses | Administer standard doses | AUC decreased 4% |
50 mg once daily | Cmax increased 14%, AUC increased 9% |
||
| Nevirapine Sertraline 589 | Green: Administer standard doses | Administer standard doses | Decreased sertaline effects |
Monitor for signs and symptoms of depression and titrate sertaline to effect |
|||
| Etravirine Sertraline 569 | Orange: Minimal data to guide interaction | minimal data to guide interaction: weigh risks and benefits of using this combination | Potiential decreaed Sertaline effects |
If coadministring, monitor for theraptutic effectiveness of Sertaline |
|||
| Efavirenz Sertraline 403 | Green: Administer standard doses | Administer standard doses | Decreased sertaline effects |
50 mg daily x 14 days | Monitor for signs and symptoms of depression and titrate sertaline to effect |
||
| Efavirenz Sertraline 402 | Green: Administer standard doses | Administer standard doses | Decreased sertaline effects |
50 mg daily x 14 days | Sertaline decreased 39%, Cmax decreased 29%, Cmin decreased 46% |
Monitor for signs and symptoms of depression and titrate sertaline to effect |
|
| Efavirenz Sertraline 401 | Green: Administer standard doses | Administer standard doses | Decreased sertaline effects |
No significant change |
50 mg daily x 14 days | Sertaline AUC decreased 39%, Cmax decreased 29%, Cmin decreased 46% |
Monitor for signs and symptoms of depression and titrate sertaline to effect |
| Elvitegravir Sertraline 131 | Green: Administer standard doses | Administer standard doses | Cmax decreased 12%; AUC decreased 6% |
50 mg single dose | Cmax increased 14%; AUC decreased 7% |
