Prezista label
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of sertraline
Drug 1
Drug 1 dose
400 mg with 100 mg ritonavir BID
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
50 mg once daily
Drug 2 effect
Cmax decrease 44%, AUC decrease 49%, Cmin decrease 49%
Clinical Effects
Potential decreased sertraline effects
Management
Titrate sertraline to effect; monitor to ensure continued response if darunavir / ritonavir initiated
Import ID
898
