Clonazepam
| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Clonazepam | Yellow: Adjust dosing | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential increased risk of sedation, respiratory depression |
Consider alternative benzodiazepines. If coadministering, use lowest effective dose and monitor for clonazepam adverse effects. |
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| Darunavir Clonazepam 994 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: weigh risks and benefits of using this combination | Potential for increased risk of clonazepam adverse effects |
Clinical monitoring is recommended |
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| Elvitegravir Clonazepam 179 | Green: Administer standard doses | Administer standard doses | Potential for increased clonazepam effects (e.g. sedation, respiratory depression) |
Frequent clinical monitoring is recommended |

