DHHS Adult ARV Guidelines
Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: weigh risks and benefits of using this combination
Drug 1
Drug 2
Mechanism
Inhibition of CYP3A4 by lenacapavir
Clinical Effects
Potential increased risk of sedation, respiratory depression
Management
Consider alternative benzodiazepines. If coadministering, use lowest effective dose and monitor for clonazepam adverse effects.
Alternative Agents
Oxazepam, lorazepam, temazepam
Info Source
