| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Dolutegravir Multivitamin 95 | Yellow: Adjust dosing | Adjust dosing to avoid reduced levels of dolutegravir | Potential decrease in antiretroviral efficacy |
Cmax decreased 35%, AUC decreased 33%, Cmin decreased 32% |
One-A-Day given simultaneously with dolutegravir | Not studied |
Administer dolutegravir 2 hours before or 6 hours after taking medications containing polyvalent cations. |
