Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of dolutegravir
Drug 1
Drug 1 dose
50 mg single dose
Drug 1 effect
Cmax decreased 35%, AUC decreased 33%, Cmin decreased 32%
Drug 2
Drug 2 dose
One-A-Day given simultaneously with dolutegravir
Drug 2 effect
Not studied
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Administer dolutegravir 2 hours before or 6 hours after taking medications containing polyvalent cations.
Import ID
95
