| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lamivudine Sorbitol 701 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Potentially decreased lamivudine efficacy |
AUC decreased 20-44% |
3.2 - 13.4 grams daily | Not studied |
Consider using alternative agents. Interaction studied with liquid formulation. If unable to avoid co-administration, monitor for virologic efficacy. |
