Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 1 dose
300 mg daily
Drug 1 effect
AUC decreased 20-44%
Drug 2
Drug 2 dose
3.2 - 13.4 grams daily
Drug 2 effect
Not studied
Clinical Effects
Potentially decreased lamivudine efficacy
Management
Consider using alternative agents. Interaction studied with liquid formulation. If unable to avoid co-administration, monitor for virologic efficacy.
Import ID
701
