| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Ritonavir Quinine 1089 | Orange: Minimal data to guide interaction | Minimal data to guide interaction: risks likely to outweigh benefits | Increased quinine effects |
Ritonavir AUC increased 21%; Cmax increased 15% |
600 mg x 1 | Quinine AUC increased 341%; Cmax increased 284% |
Avoid combination and use alternative agents. If combination must be used a potential four-fold reduction in quinine dosage may be needed |
