Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 1 dose
200 mg Q12 h x 9 days
Drug 1 effect
Ritonavir AUC increased 21%; Cmax increased 15%
Drug 2
Drug 2 dose
600 mg x 1
Drug 2 effect
Quinine AUC increased 341%; Cmax increased 284%
Clinical Effects
Increased quinine effects
Management
Avoid combination and use alternative agents. If combination must be used a potential four-fold reduction in quinine dosage may be needed
Import ID
1089
