| Interaction Color Code | Clinical Bottom Line | Clinical Effects | Drug 1 effect | Drug 2 dose | Drug 2 effect | Management | |
|---|---|---|---|---|---|---|---|
| Lenacapavir Naloxegol | Yellow: Adjust dosing | Minimal data to guide interaction: risks likely to outweigh benefits | Increased risk of naloxegol adverse effects |
Consider using alternative agents. If coadministration is unavoidable, decrease dose of naloxegol and monitor for adverse reactions. |
|||
| Darunavir Naloxegol 948 | Red: Avoid combination | Do not coadminister: Potential for increased naloxegol levels | Potential for increased risk of precipitating opioid withdrawal |
Contraindicated. Use alternative agents. |
